Journal
INTERNATIONAL REVIEWS OF IMMUNOLOGY
Volume 29, Issue 4, Pages 371-402Publisher
TAYLOR & FRANCIS INC
DOI: 10.3109/08830185.2010.489658
Keywords
cytotoxicity; CD4(+) T cells; Epstein-Barr virus; cancer
Categories
Funding
- European Community [037874]
- Alleanza Contro il Cancro [ACC-4]
- Italian Ministry of Health, Federica Per La Vita Foundation
- Associazione Italiana per la Ricerca sul Cancro
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Our knowledge on the physiological role of CD4(+) T lymphocytes has improved in the last decade: available data convincingly demonstrate that, besides the 'helper' activity, CD4(+) T cells may be also endowed with lytic properties. The cytotoxic function of these effector cells has a relevant role in the control of pathogenic infections and in mediating antitumor immune responses. On these bases, several immunotherapeutic approaches exploiting the cytotoxic properties of CD4(+) T cells are under investigation. This review summarizes available data supporting the functional and therapeutic relevance of cytotoxic CD4(+) T cells, with a particular focus on Epstein-Barr virus (EBV)-related disorders.
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