Journal
INTERNATIONAL REVIEWS OF IMMUNOLOGY
Volume 29, Issue 6, Pages 608-625Publisher
TAYLOR & FRANCIS INC
DOI: 10.3109/08830185.2010.522282
Keywords
acute phase response; biocompatibility; bio-incompatibility; cytokines; dialyzer; hemodialysis; hemodialysis membranes; inflammation; liver; lymphocytes
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Long-term hemodialysis treatment results in chronic monocyte activation with cytokine release. It generates Treg induction with potential immune dysfunction and associated clinical complications. Recent immunological data and preliminary clinical evidence suggest that synthetic polymers and vitamin E coated membranes are associated with a significant improvement in hemodialysis tolerance when compared to cellulose membranes. The aim of this review is to update cytokine release, T-cell polarization, and its clinical impact in patients under extracorporeal hemodialysis comparing traditional cellulose to synthetic/vitamin E coated membranes.
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