Journal
MOLECULAR ONCOLOGY
Volume 9, Issue 5, Pages 951-959Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.molonc.2015.02.011
Keywords
Biomarker-driven clinical trials; Platform trials; Basket trials; Bayesian adaptive clinical trials
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Funding
- NCI NIH HHS [P50 CA100632, P30 CA016672] Funding Source: Medline
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Clinical trials are the final links in the chains of knowledge and for determining the roles of therapeutic advances. Unfortunately, in an important sense they are the weakest links. This article describes two designs that are being explored today: platform trials and basket trials. Both are attempting to merge clinical research and clinical practice. (C) 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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