Journal
MOLECULAR NUTRITION & FOOD RESEARCH
Volume 59, Issue 12, Pages 2556-2564Publisher
WILEY
DOI: 10.1002/mnfr.201500375
Keywords
CLOCK gene; CORDIOPREV clinical trial; Coronary heart disease; Gene-diet interaction; Lipid metabolism
Categories
Funding
- Fundacion Patrimonio Comunal Olivarero
- Junta de Andalucia (Consejeria de Salud, Consejeria de Agricultura y Pesca, Consejeria de Innovacion, Ciencia y Empresa)
- Diputaciones de Jaen y Cordoba
- Centro de Excelencia en Investigacion sobre Aceite de Oliva y Salud
- Ministerio de Medio Ambiente, Medio Rural y Marino, Gobierno de Espana
- European community [289511]
- Plan Nacional de I + D + I
- ISCIII-Subdireccion General de Evaluacion
- Fondo Europeo de Desarrollo Regional (FEDER) [FIS PI10/01041, AGL2012/39615, PI13/00185]
- Ministerio de Ciencia e Innovacion [AGL2009-122270]
- Consejeria de Salud, Junta de Andalucia [PI-0058/10, PI-0206/13]
- Proyecto de Excelencia, Consejeria de Economia, Innovacion, Ciencia y Empleo [CVI-7450]
- Merck Serono
- Fundacion 2000 (Clinical research in Cardiometabolic)
- ISCIII research contract (Programa Rio-Hortega)
Ask authors/readers for more resources
Scope: Single nucleotide polymorphisms (SNPs) of the circadian locomotor output cycles kaput (CLOCK) gene have been associated with cardiometabolic conditions such as obesity and dyslipidemia. Our aim was to examine whether the chronic consumption of two healthy diets interacts with SNPs of the CLOCK gene in order to improve lipid metabolism and inflammation status in patients with coronary heart disease (CHD). Methods and results: The diets were low-fat (LF) diet and Mediterranean diet (MedDiet). CLOCK SNPs (rs1801260, rs3749474, rs4580704) and the study procedures were performed in 897 patients from the CORDIOPREV clinical trial. After 12 months of intervention, we found significant gene-diet interactions between rs4580704 SNP and the LF diet. Specifically, major allele carriers C/C displayed a greater decrease in high sensitivity C-reactive protein (p < 0.001) and a significant increase in HDL/apolipoprotein A1 ratio (p = 0.029) than minor G allele carriers (G/G + C/G). No other gene-diet interactions were observed in this research. Conclusion: These results suggest that rs4580704 SNP interacts with the LF diet improving inflammation status and dyslipidemia related with CHD. The shift toward personalized nutrition based on gene-nutrient interactions may be suitable for promoting cardiovascular health in patients with CHD.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available