Journal
MOLECULAR NEUROBIOLOGY
Volume 53, Issue 6, Pages 4094-4125Publisher
SPRINGER
DOI: 10.1007/s12035-015-9337-5
Keywords
Alzheimer's disease; Amyotrophic lateral sclerosis; Antioxidant defense molecule; Non-enzymatic and enzymatic antioxidant; Oxidative stress biomarker; Parkinson's disease; ESR-electron spin resonance; IST-immuno-spin trapping technique
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Funding
- Jagiellonian University [K/ZDS/004127]
- National Science Centre [UMO-2011/01/B/NZ4/00708]
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The pathophysiologies of neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), Parkinson's disease (PD), and Alzheimer's disease (AD), are far from being fully explained. Oxidative stress (OS) has been proposed as one factor that plays a potential role in the pathogenesis of neurodegenerative disorders. Clinical and preclinical studies indicate that neurodegenerative diseases are characterized by higher levels of OS biomarkers and by lower levels of antioxidant defense biomarkers in the brain and peripheral tissues. In this article, we review the current knowledge regarding the involvement of OS in neurodegenerative diseases, based on clinical trials and animal studies. In addition, we analyze the effects of the drug-induced modulation of oxidative balance, and we explore pharmacotherapeutic strategies for OS reduction.
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