Journal
MOLECULAR NEUROBIOLOGY
Volume 53, Issue 3, Pages 1905-1924Publisher
SPRINGER
DOI: 10.1007/s12035-015-9143-0
Keywords
Alzheimer' disease; Soluble A beta oligomers; A beta
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Funding
- National Natural Science Foundation of China [81471309, 81371406, 81171209]
- Shandong Provincial Collaborative Innovation Center for Neurodegenerative Disorders
- Shandong Provincial Outstanding Medical Academic Professional Program
- Qingdao Key Health Discipline Development Fund
- Qingdao Outstanding Health Professional Development Fund
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Alzheimer's disease (AD) is a common neurodegenerative disease characterized by amyloid plaque and neurofibrillary tangles (NFT). With the finding that soluble nonfibrillar A beta levels actually correlate strongly with the severity of the disease, the initial focus on amyloid plaques shifted to the contemporary concept that AD memory failure is caused by soluble A beta oligomers. The soluble A beta are known to be more neurotoxicthan fibrillar A beta species. In this paper, we summarize the essential role of soluble A beta oligomers in AD and discuss therapeutic strategies that target soluble A beta oligomers.
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