Journal
INTERNATIONAL JOURNAL OF UROLOGY
Volume 21, Issue -, Pages 18-25Publisher
WILEY
DOI: 10.1111/iju.12308
Keywords
afferent pathway; bladder pain syndrome; cytokine; interstitial cystitis; nerve growth factor
Categories
Funding
- National Institutes of Health [DK088836, P01 DK044935]
- Department of Defense [W81XWH-12-1-0565]
- Paralyzed Veterans of America [2793]
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Bladder pain syndrome/interstitial cystitis is a disease with lower urinary tract symptoms, such as bladder pain and urinary frequency, which results in seriously impaired quality of life of patients. The extreme pain and urinary frequency are often difficult to treat. Although the etiology of bladder pain syndrome/interstitial cystitis is still not known, there is increasing evidence showing that afferent hyperexcitability as a result of neurogenic bladder inflammation and urothelial dysfunction is important to the pathophysiological basis of symptom development. Further investigation of the pathophysiology will lead to the effective treatment of patients with bladder pain syndrome/interstitial cystitis.
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