Journal
MOLECULAR NEUROBIOLOGY
Volume 53, Issue 6, Pages 4159-4172Publisher
HUMANA PRESS INC
DOI: 10.1007/s12035-015-9324-x
Keywords
Hydrogen sulfide; Vascular dementia; Long-term depression; Hippocampus
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Funding
- National Natural Science Foundation of China [31400986, 11232005]
- Applied Basic Research Programs of Science and Technology Commission Foundation of Tianjin [14JCQNJC11800, 14JCZDJC35000]
- 111Project [B08011]
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Our previous study has demonstrated that hydrogen sulfide (H2S) attenuates neuronal injury induced by vascular dementia (VD) in rats, but the mechanism is still poorly understood. In this study, we aimed to investigate whether the neuroprotection of H2S was associated with synaptic plasticity and try to interpret the potential underlying mechanisms. Adult male Wistar rats were suffered the ligation of bilateral common carotid arteries. At 24 h after surgery, rats were administered intraperitoneally with sodium hydrosulfide (NaHS, 5.6 mg center dot kg(-1)center dot day(-1)), a H2S donor, for 3 weeks in the VD+NaHS group and treated intraperitoneally with saline in the VD group respectively. Our results demonstrated that NaHS significantly decreased the level of glutamate. It obviously ameliorated cognitive flexibility as well as the spatial learning and memory abilities by Morris water maze. Moreover, NaHS significantly improved the long-term depression (LTD), and was able to elevate the expression of N-methyl-d-aspartate receptor subunit 2A, which plays a pivotal role in synaptic plasticity. Interestingly, NaHS decreased the phosphorylation of Akt, and it could maintain the activity of glycogen synthase kinase-3 beta (GSK-3 beta). Surprisingly, NaHS triggered the canonical Notch pathway by increasing expressions of Jagged-1 and Hes-1. These findings suggest that NaHS prevents synaptic plasticity from VD-induced damage partly via Akt/GSK-3 beta pathway and Notch signaling pathway.
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