Journal
INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE
Volume 22, Issue 10, Pages 1227-+Publisher
INT UNION AGAINST TUBERCULOSIS LUNG DISEASE (I U A T L D)
DOI: 10.5588/ijtld.18.0027
Keywords
CLNT; lymphadenectomy; post-operative wound healing; interleukin 6; vascular endothelial growth factor A
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Funding
- National Science and Technology Major Project [2017ZX10201301-003]
- National Science Foundation of China, Beijing [81271794, 81501365]
- Shanghai Science and Technology Commission, Shanghai, China [134119a9100]
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SETTING: A high proportion of tuberculosis (TB) patients experience delayed wound healing after surgery, and the specific reasons for this phenomenon are not yet clear. OBJECTIVE: To analyse cytokine and growth factors at surgical sites to determine their contribution to delayed wound healing in patients with cervical lymph node TB (CLNT). DESIGN: We measured levels of interleukin (IL) 1 beta, IL-6, IL-10, IL-22, epidermal growth factor, fibroblast growth factor-2, interferon-gamma, tumour necrosis factor alpha and vascular endothelial growth factor A (VEGF-A) in cervical wound drainage fluid from 36 CLNT patients who underwent lymphadenectomy and in 24 thyroidectomy patients. RESULTS: Wound drainage fluid from CLNT patients showed higher IL-6 (P = 0.007) and VEGF-A (P < 0.001) levels than control thyroidectomy patients (P < 0.05). CLNT patients with a delayed healing time (>5 days; n= 18) showed higher IL-6 (P=0.002) and VEGF-A (P < 0.001) levels in wound drainage fluid than CLNT patients with normal healing times (<= 5 days; n = 18). IL-6 (OR 11.280, 95%CI 1.413-90.028; P=0.022) and VEGF-A (OR 13.510, 95%CI 2.168-84.182; P = 0.005) can independently and significantly predict wound healing time in CLNT patients. CONCLUSION: These findings demonstrate that high IL-6 and VEGF-A levels in the post-operative wound fluid of CLNT patients correlate with delayed wound healing.
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