Journal
MOLECULAR MEDICINE REPORTS
Volume 12, Issue 5, Pages 6461-6466Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/mmr.2015.4233
Keywords
apigenin; head and neck; adenoid cystic carcinoma; glucose transporter-1; anticancer effect
Categories
Funding
- Health Department of Zhejiang Province, China [2012KYB206]
- National Natural Science Foundation of China [81172562, 81372903]
Ask authors/readers for more resources
Apigenin is a natural phyto-oestrogen flavonoid, which exerts various biological effects, including anti-oxidative, anti-inflammatory and anticancer activities. In addition, apigenin has recently been reported to target hypoxic markers; however, there are currently no studies regarding the association between apigenin and glucose transporter-1 (GLUT-1) in adenoid cystic carcinoma (ACC). The present study investigated whether apigenin inhibits the proliferation of ACC cells or suppresses the expression of GLUT-1 in ACC cells. The results of the present study demonstrated that apigenin inhibits ACC-2 cell growth in a dose- and time-dependent manner. Treatment with apigenin also induced apoptosis and G(2)/M-phase arrest in a dose- and time-dependent manner. Corresponding with the above results, the expression levels of GLUT-1 were significantly decreased following treatment in a dose- and time-dependent manner. These results suggest that the inhibition of ACC-2 cell growth by apigenin may be due to the decreased expression of GLUT-1.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available