Journal
MOLECULAR MEDICINE REPORTS
Volume 12, Issue 3, Pages 4015-4021Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/mmr.2015.3930
Keywords
high-density lipoprotein; scavenger receptor class B type I; adenosine triphosphate-binding cassette sub-family A member 1; reverse cholesterol transport
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High density lipoproteins (Hill.) are heterogeneous particles regarding their size and composition. They have vital functions in reverse cholesterol transport (RCT). RCT occurs when lipid-free apolipoprotein AI recruits cholesterol and phospholipid to form nascent HDL particles. Adenosine triphosphate-binding cassette transporters and scavenger receptor Class B type I were found to be associated with the synthesis of HDL. Experimental studies have identified several potential anti-atherogenic effects of HDL, including promotion of fliacrophage cholesterol outflow as well as anti-inflammatory and anti-thrombotic effects. HDL can also transport microRNAs. This review mainly summarizes the present knowledge of HDL synthesis and metabolism.
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