Journal
INTERNATIONAL JOURNAL OF STROKE
Volume 8, Issue 3, Pages 214-218Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1111/j.1747-4949.2011.00762.x
Keywords
biomarker; copeptin; stroke; risk stratification; thrombolysis; TIA
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Funding
- B.R.A.H.M.S Biomarkers Clinical Diagnostics Division, Thermo Fisher Scientific, Neuendorfstr
- Hennigsdorf-Berlin Germany [16761]
- Foundation of the Inselspital Bern (Switzerland)
- Foundation Scientia et Arte, Bern (Switzerland)
- De Quervain's Grant for young clinical investigators, Clinical Trials Unit, Bern (Switzerland)
- Swiss National Science Foundation (SNF)
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Rationale Copeptin independently predicts functional outcome and mortality at 90days and one-year after ischemic stroke. In patients with transient ischemic attack, elevated copeptin values indicate an increased risk of further cerebrovascular events. Aims The Copeptin Risk Stratification (CoRisk) study aims to validate the predictive value of copeptin in patients with ischemic stroke and transient ischemic attack. In patients with ischemic stroke, the CoRisk study aims to further explore the effect of treatment (i.e. thrombolysis) on the predictive value of copeptin. Design Prospective observational multicenter study analyzing three groups of patients, i.e. patients with ischemic stroke treated with and without thrombolysis and patients with transient ischemic attack. Outcomes Primary end-point: In patients with ischemic stroke, the primary end-point includes disability (modified Rankin scale from 3 to 5) and mortality (modified Rankin scale 6) at three-months after stroke. In patients with transient ischemic attack, the primary end-point is a recurrent ischemic cerebrovascular event (i.e. ischemic stroke or recurrent transient ischemic attack). Secondary end-point: In patients with ischemic stroke, the secondary end-points include in-house complications (i.e. symptomatic intracerebral hemorrhage, malignant edema, aspiration pneumonia or seizures during hospitalization, and in-house mortality).
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