Journal
INTERNATIONAL JOURNAL OF STROKE
Volume 3, Issue 2, Pages 92-97Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1111/j.1747-4949.2008.00169.x
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A single pill containing a statin, thiazide diuretic, beta-blocker, angiotensin receptor antagonist, folate and ASA has been proposed for all people over age 55, with the aim of reducing cardiovascular disease by 80%. Unfortunately, there are insurmountable problems with choosing appropriate constituents of any such single remedy. Adverse effects, drug interactions, inter-individual variation in drug metabolism, and underlying causes of hypertension that differ between patients require individualized therapy. A single pill that will succeed in all patients is not only practically, but conceptually, an inappropriate approach for the prevention of cardiovascular disease.
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