Journal
MOLECULAR IMMUNOLOGY
Volume 67, Issue 2, Pages 117-130Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.molimm.2015.01.028
Keywords
Complement; Immunology; Antibody; Therapy; Antibody engineering; Cancer
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Complement is recognized as a key player in a wide range of normal as well as disease-related immune, developmental and homeostatic processes. Knowledge of complement components, structures, interactions, and cross-talk with other biological systems continues to grow and this leads to novel treatments for cancer, infectious, autoimmune- or age-related diseases as well as for preventing transplantation rejection. Antibodies are superbly suited to be developed into therapeutics with appropriate complement stimulatory or inhibitory activity. Here we review the design, development and future of antibody-based drugs that enhance or dampen the complement system. (C) 2015 The Authors. Published by Elsevier Ltd.
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