Journal
INTERNATIONAL JOURNAL OF SPORTS MEDICINE
Volume 29, Issue 10, Pages 856-863Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-2007-989424
Keywords
exercise; infections; antibodies; natural killer cells; IgA; respiratory burst
Categories
Funding
- Defense Advanced Research Projects Agency (DARPA)
- Army Research Office (ARO) [W911NF-06-0014]
- Quercegen Pharma (Newton, MA) [QU995]
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This Study measured the influence of the flavonoid quercetin on immune changes and incidence rates of upper respiratory tract infections in ultramarathoners competing in the 160-km Western States Endurance Run. Sixty-three runners were randomized to quercetin and placebo groups, and under double-blinded methods ingested 1000 mg/day quercetin for 3 wks before, during, and 2 wks after the race. Thirty-nine of the 63 subjects (n = 18 for quercetin, n = 21 for placebo) finished the race and provided blood and saliva samples the morning before the race and 15 - 30 min postrace. Upper respiratory tract infections were assessed during the week before and the 2-wk period after the race using an illness symptom checklist. Race times did not differ significantly between quercetin and placebo groups. Significant pre- to postrace decreases were measured for natural killer cells (43%), granulocyte respiratory burst activity (55%), and salivary IgA output (48%), and increases for neutrophil (288%) and monocyte (211%) cell counts, with no significant group differences. Postrace illness rates did not differ between groups. In conclusion, quercetin Supplementation for 3 wks before and 2 wks after the Western States Endurance Run had no effect on illness rates, perturbations in leukocyte subset counts, or decreases in granulocyte respiratory burst activity and salivary IgA.
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