Journal
MOLECULAR IMAGING AND BIOLOGY
Volume 17, Issue 6, Pages 763-769Publisher
SPRINGER
DOI: 10.1007/s11307-015-0848-2
Keywords
Micro-CT imaging; Iron oxide nanoparticles; Magnetic fluid hyperthermia; In vivo; Therapeutic efficiency; Tumor volume; Temperature distribution; Intratumoral MNP distributon
Funding
- European Seventh Framework Program (FP7) [262943]
- Federal State Thuringia
- European Union (EFRE
- European Fond for regional development)
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Heterogeneous magnetic nanoparticle (MNP) distributions within tumors can cause regions of temperature under dosage and reduce the therapeutic efficiency. Here, micro-computed tomography (CT) imaging was used as a tool to determine the MNP distribution in vivo. The therapeutic success was evaluated based on tumor volume and temperature distribution. Tumor-bearing mice were intratumorally injected with iron oxide particles. MNP distribution was assessed by micro-CT with a low radiation dose protocol. MNPs were clearly visible, and the exact distribution to nontumor structures was detected by micro-CT. Knowledge of the intratumoral MNP distribution allowed the generation of higher temperatures within the tumor and led to higher temperature values after exposure to an alternating magnetic field (AMF). Consequently, the tumor size after 28 days was reduced to 14 and 73 % of the initial tumor volume for the MNP/AMF/CT and MNP/AMF groups, respectively. The MNP distribution pattern mainly governed the generated temperature spots in the tumor. Knowing the MNP distribution enabled individualized hyperthermia treatment and improved the overall therapeutic efficiency.
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