Journal
INTERNATIONAL JOURNAL OF SPORT NUTRITION AND EXERCISE METABOLISM
Volume 22, Issue 6, Pages 430-437Publisher
HUMAN KINETICS PUBL INC
DOI: 10.1123/ijsnem.22.6.430
Keywords
flavonoid; muscle soreness; DOMS; strength loss
Categories
Funding
- U.S. Army [W911QY-07-C-0001]
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The flavonoid quercetin is purported to have potent antioxidant and anti-inflammatory properties. This study examined if quercetin supplementation attenuates indicators of exercise-induced muscle damage in a double-blind laboratory study. Thirty healthy subjects were randomized to quercetin (QU) or placebo (PL) supplementation and performed 2 separate sessions of 24 eccentric contractions of the elbow flexors. Muscle strength, soreness, resting arm angle, upper arm swelling, serum creatine kinase (CK) activity, plasma quercetin (PQ), interleukin-6 (IL-6), and C-reactive protein (CRP) were assessed before and for 5 d after exercise. Subjects then ingested nutrition bars containing 1,000 mg/d QU or PL for 7 d before and 5 d after the second exercise session, using the opposite arm. PQ reached 202 +/- 52 ng/ml after 7 d of supplementation and remained elevated during the 5-d postexercise recovery period (p < .05). Subjects experienced strength loss (peak = 47%), muscle soreness (peak = 39 +/- 6 mm), reduced arm angle (-7 degrees +/- 1 degrees), CK elevations (peak = 3,307 +/- 1,481 U/L), and arm swelling (peak = 11 +/- 2 mm; p < .0001), indicating muscle damage and inflammation; however, differences between treatments were not detected. Eccentric exercise did not alter plasma IL-6 (peak = 1.9 pg/ml) or CRP (peak = 1.6 mg/L) relative to baseline or by treatment. QU supplementation had no effect on markers of muscle damage or inflammation after eccentric exercise of the elbow flexors.
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