4.4 Article

Preclinical Characterization of the Phosphodiesterase 10A PET Tracer [11C]MK-8193

Related references

Note: Only part of the references are listed.
Article Chemistry, Medicinal

Discovery of [11C]MK-8193 as a PET tracer to measure target engagement of phosphodiesterase 10A (PDE10A) inhibitors

Christopher D. Cox et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2015)

Article Pharmacology & Pharmacy

In Vivo Pharmacological Characterization of TAK-063, a Potent and Selective Phosphodiesterase 10A Inhibitor with Antipsychotic-Like Activity in Rodents

Kazunori Suzuki et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2015)

Article Pharmacology & Pharmacy

AMG 580: A Novel Small Molecule Phosphodiesterase 10A (PDE10A) Positron Emission Tomography Tracer

Hang Chen et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2015)

Article Radiology, Nuclear Medicine & Medical Imaging

In Vivo Assessment and Dosimetry of 2 Novel PDE10A PET Radiotracers in Humans: 18F-MNI-659 and 18F-MNI-654

Olivier Barret et al.

JOURNAL OF NUCLEAR MEDICINE (2014)

Article Radiology, Nuclear Medicine & Medical Imaging

Phosphodiesterase 10A PET Radioligand Development Program: From Pig to Human

Christophe Plisson et al.

JOURNAL OF NUCLEAR MEDICINE (2014)

Article Biotechnology & Applied Microbiology

Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework

David Cook et al.

NATURE REVIEWS DRUG DISCOVERY (2014)

Article Radiology, Nuclear Medicine & Medical Imaging

Initial characterization of a PDE10A selective positron emission tomography tracer [11C]AMG 7980 in non-human primates

Dah-Ren Hwang et al.

NUCLEAR MEDICINE AND BIOLOGY (2014)

Article Radiology, Nuclear Medicine & Medical Imaging

Quantification of 18F-JNJ-42259152, a Novel Phosphodiesterase 10A PET Tracer: Kinetic Modeling and Test-Retest Study in Human Brain

Koen Van Laere et al.

JOURNAL OF NUCLEAR MEDICINE (2013)

Article Chemistry, Medicinal

Discovery of tetrahydropyridopyrimidine phosphodiesterase 10A inhibitors for the treatment of schizophrenia

Izzat T. Raheem et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)

Article Biochemistry & Molecular Biology

Radiosynthesis and in vivo evaluation of [11C]MP-10 as a PET probe for imaging PDE10A in rodent and non-human primate brain

Zhude Tu et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2011)

Article Radiology, Nuclear Medicine & Medical Imaging

Radiosynthesis and in vivo evaluation of [11C]MP-10 as a positron emission tomography radioligand for phosphodiesterase 10A

Christophe Plisson et al.

NUCLEAR MEDICINE AND BIOLOGY (2011)

Review Biochemistry & Molecular Biology

Basal ganglia pathology in schizophrenia: dopamine connections and anomalies

Emma Perez-Costas et al.

JOURNAL OF NEUROCHEMISTRY (2010)

Article Pharmacology & Pharmacy

Inhibition of Phosphodiesterase 10A Increases the Responsiveness of Striatal Projection Neurons to Cortical Stimulation

Sarah Threlfell et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2009)

Article Pharmacology & Pharmacy

Phosphodiesterase 10A Inhibitor Activity in Preclinical Models of the Positive, Cognitive, and Negative Symptoms of Schizophrenia

Steven M. Grauer et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2009)

Article Pharmacology & Pharmacy

Preclinical characterization of selective phosphodiesterase 10A inhibitors: A new therapeutic approach to the treatment of schizophrenia

C. J. Schmidt et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2008)

Review Radiology, Nuclear Medicine & Medical Imaging

In vivo site-directed radiotracers: a mini-review

Shil Patel et al.

NUCLEAR MEDICINE AND BIOLOGY (2008)

Review Endocrinology & Metabolism

Consensus nomenclature for in vivo imaging of reversibly binding radioligands

Robert B. Innis et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2007)

Article Cell Biology

Immunohistochemical localization of phosphodiesterase 10A in multiple mammalian species

Timothy M. Coskran et al.

JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY (2006)

Review Pharmacology & Pharmacy

Cyclic nucleotide phosphodiesterases: Molecular regulation to clinical use

Andrew T. Bender et al.

PHARMACOLOGICAL REVIEWS (2006)

Article Neurosciences

PDE10A inhibition reverses subchronic PCP-induced deficits in attentional set-shifting in rats

JS Rodefer et al.

EUROPEAN JOURNAL OF NEUROSCIENCE (2005)