Journal
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
Volume 17, Issue 4, Pages 369-383Publisher
WILEY
DOI: 10.1111/1756-185X.12280
Keywords
angiogenesis; cytokines; hypoxia; RA; VEGF
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Angiogenesis is an important phenomenon in the pathogenesis of some diseases, such as numerous types of tumors and autoimmunity, and also a number of soluble and cell-bound factors may stimulate neovascularization in inflammatory reaction processes. Here, by highlighting the significance of angiogenesis reaction in rheumatoid arthritis (RA), we will mainly focus on the role of various growth factors, cytokines, enzymes, cells, hypoxic conditions and transcription factors in the angiogenic process and we will then explain some therapeutic strategies based on blockage of angiogenesis and modification of the vascular pathology in RA.
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