Journal
MOLECULAR DIVERSITY
Volume 20, Issue 1, Pages 299-344Publisher
SPRINGER
DOI: 10.1007/s11030-015-9629-8
Keywords
Spiroheterocyclic systems; Isatin; Oxindoles; Multicomponent reactions (MCRs); Cycloadditions; Highly functionalised molecules; Diversity-oriented synthesis; DOS
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Spirooxindoles are important synthetic targets possessing extended biological activity and drug discovery applications. This review focuses on the various strategies for the enantioselective synthesis of spirocyclic oxindoles relying on reports over the past decade and from earlier work. The spirooxindoles in this review are separated into three structural classes, and then further categorized into the method type from which the spirocycle is generated.
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