Journal
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
Volume 82, Issue 3, Pages 1047-1057Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.ijrobp.2011.07.020
Keywords
body radiation therapy; Conformal radiotherapy; Brachytherapy; Selective internal radiotherapy; Whole liver radiotherapy; Liver metastases
Funding
- Varian Medical Systems
- Lundbeck Centre for Interventional Research in Radiation Oncology (CIRRO)
- A.P. Moller and Wife Chastine Maersk McKinney Mollers Foundation
- Elekta
- Bayer
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Over the past decade, there has been an increasing use of radiotherapy (RT) for the treatment of liver metastases. Most often, ablative doses are delivered to focal liver metastases with the goal of local control and ultimately improving survival. In contrast, low-dose whole-liver RT may be used for the palliation of symptomatic diffuse metastases. This review examines the available clinical data for both approaches. The review found that RT is effective both for local ablation of focal liver metastases and for palliation of patients with symptomatic liver metastases. However, there is a lack of a high level of evidence from randomized clinical trials. (C) 2012 Elsevier Inc.
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