Journal
MOLECULAR CELL
Volume 58, Issue 4, Pages 568-574Publisher
CELL PRESS
DOI: 10.1016/j.molcel.2015.02.032
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Funding
- Howard Hughes Medical Institute Funding Source: Medline
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Few discoveries transform a discipline overnight, but biologists today can manipulate cells in ways never possible before, thanks to a peculiar form of prokaryotic adaptive immunity mediated by clustered regularly interspaced short palindromic repeats (CRISPR). From elegant studies that deciphered how these immune systems function in bacteria, researchers quickly uncovered the technological potential of Cas9, an RNA-guided DNA cleaving enzyme, for genome engineering. Here we highlight the recent explosion in visionary applications of CRISPR-Cas9 that promises to usher in a new era of biological understanding and control.
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