Journal
MOLECULAR CELL
Volume 57, Issue 6, Pages 1099-1109Publisher
CELL PRESS
DOI: 10.1016/j.molcel.2015.01.035
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Funding
- Intramural Research Programs of the Eunice Kennedy Shriver National Institute of Child Health and Human Development
- National Library of Medicine as well as the Pharmacology Research Associate Program
- NIH Undergraduate Scholarship Program
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The highly structured, cis-encoded RNA elements known as riboswitches modify gene expression upon binding a wide range of molecules. The yybP-ykoY motif was one of the most broadly distributed and numerous bacterial riboswitches for which the cognate ligand was unknown. Using a combination of in vivo reporter and in vitro expression assays, equilibrium dialysis, and northern analysis, we show that the yybP-ykoY motif responds directly to manganese ions in both Escherichia coli and Bacillus subtilis. The identification of the yybP-ykoY motif as a manganese ion sensor suggests that the genes that are preceded by this motif and encode a diverse set of poorly characterized membrane proteins have roles in metal homeostasis.
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