Journal
MOLECULAR CELL
Volume 57, Issue 6, Pages 949-950Publisher
CELL PRESS
DOI: 10.1016/j.molcel.2015.03.007
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Funding
- NIA NIH HHS [R01 AG024984] Funding Source: Medline
- NICHD NIH HHS [R01 HD069184] Funding Source: Medline
- NIMH NIH HHS [R01 MH105128] Funding Source: Medline
- NINDS NIH HHS [R01 NS048271, R01 NS047344, P01 NS097206] Funding Source: Medline
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In this issue of Molecular Cell, Laurent et al. (2015) demonstrated that a neuron-enriched isoform of LSD1 (LSD1+ 8a) within a SVIL-containing complex exhibits H3K9me1/2-specific demethylation activity. Such activity was crucial for gene activation during mammalian neurogenesis.
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