Journal
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
Volume 76, Issue 3, Pages S28-S35Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.ijrobp.2009.07.1753
Keywords
Optic; Nerve; Chiasm; Tolerance; Radiotherapy
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Publications relating radiation toxicity of the optic nerves and chiasm to quantitative dose and dose-volume measures were reviewed. Few studies have adequate data for dose-volume outcome modeling. The risk of toxicity increased markedly at doses >60 Gy at approximate to 1.8 Gy/fraction and at >12 Gy for single-fraction radiosurgery. The evidence is strong that radiation tolerance is increased with a reduction in the dose per fraction. Models of threshold tolerance were examined. (C) 2010 Elsevier Inc.
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