Journal
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
Volume 78, Issue 4, Pages 983-991Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.ijrobp.2010.06.052
Keywords
Radiotherapy; Hyposalivation; Xerostomia; Prevention; Palliative care; Gene transfer; Stem cell therapy
Funding
- National Institute of Dental and Craniofacial Research [R13 DE 19330]
- National Cancer Institute
- National Institutes of Health Office of Rare Diseases
- University of Connecticut School of Dental Medicine
- Carolinas Medical Center
- Multinational Association of Supportive Care in Cancer
- International Society of Oral Oncology
- Endo Pharmaceuticals, Inc.
- EUSA Pharma
- Biovitrum and Helsinn Healthcare SA
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The most significant long-term complication of radiotherapy in the head-and-neck region is hyposalivation and its related complaints, particularily xerostomia. This review addresses the pathophysiology underlying irradiation damage to salivary gland tissue, the consequences of radiation injury, and issues contributing to the clinical management of salivary gland hypofunction and xerostomia. These include ways to (1) prevent or minimize radiation injury of salivary gland tissue, (2) manage radiation-induced hyposalivation and xerostomia, and (3) restore the function of salivary gland tissue damaged by radiotherapy. (C) 2010 Elsevier Inc.
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