4.2 Article

THE RELATIONSHIP BETWEEN PSYCHOLOGICAL FACTORS, INFLAMMATION, AND NUTRITION IN PATIENTS WITH CHRONIC RENAL FAILURE UNDERGOING HEMODIALYSIS

Journal

INTERNATIONAL JOURNAL OF PSYCHIATRY IN MEDICINE
Volume 44, Issue 2, Pages 105-118

Publisher

SAGE PUBLICATIONS INC
DOI: 10.2190/PM.44.2.b

Keywords

cytokine; albumin; emotion; renal disease; structural equation modeling

Categories

Funding

  1. National Science Council, Taiwan [NSC 96-2314-B-182A-090-MY2]

Ask authors/readers for more resources

Objective: Hemodialysis has an adverse impact on the immunological, nutritional, and emotional status of patients. The biochemical markers of inflammation and nutrition were studied as well as the relationship of these factors to emotional symptoms. Method: One hundred and ninety-five patients undergoing hemodialysis were enrolled. The mean age was 58.5 years. Emotional symptoms were assessed using the Mini International Neuropsychiatric Interview, Hospital Anxiety and Depression Scale, Chalder Fatigue Scale, and Short-form Health-related Quality of Life. Venus blood was collected for laboratory assessment of serum hemoglobin, albumin, ferritin, C-reactive protein, interleukin (IL) 1 beta), IL-6, and tumor necrosis factor alpha. Results: Among the 195 subjects (92 men and 103 women), 47 (24.1%) fulfilled the criteria for a major depressive disorder (MDD). The IL-6 level in patients with a MDD was significantly higher than in the patients without a MDD. Significant correlation was observed among the following factors: IL-6, fatigue, and quality of life for both physical and mental components. The albumin levels showed a significant correlation with the IL-6 and depression scores. Conclusions: These results show that the serum levels of albumin and IL-6 might be laboratory markers associated with the expression of emotional symptoms in patients undergoing hemodialysis. Prospective studies are needed to determine the causal relationships among these variables. (Int'l J. Psychiatry in Medicine 2012;44:105-118)

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.2
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available