Journal
INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE
Volume 19, Issue 2, Pages 84-89Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/13651501.2014.981546
Keywords
Body dysmorphic disorder; antipsychotic; selective serotonin reuptake inhibitor
Categories
Funding
- Janssen
- Lundbeck
- Servier
- Novartis
- Bristol-Myers Squibb
- Cephalon
- International College of OC Spectrum Disorders
- International Society for Addiction
- ECNP
- BAP
- WHO
- Royal College of Psychiatrists
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Objectives. A retrospective naturalistic case note study to determine the frequency, co-morbidity and treatment-response of body dysmorphic disorder (BDD). Methods. Records from 280 patients attending a highly specialised obsessive-compulsive disorder (OCD)/BDD service were analysed. The clinical outcome was measured either through scoring of the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) for OCD/BDD, or textual analysis of case notes for evidence of symptomatic improvement, treatment tolerability, and premature disengagement. Results. A total of 32 patients (11.43%) were diagnosed with BDD. Of these, 28 (87.5%) had at least one co-morbidity. All patients were offered cognitive behavioural therapy (CBT) and selective serotonin reuptake inhibitor (SSRI). Adjunctive low-dose antipsychotic was prescribed for 21 (66%) patients. Overall, 18/32 (56%) responded, and 7/32 (22%) disengaged prematurely. Patients offered antipsychotic, SSRI and CBT (n = 21) were compared with those offered SSRI and CBT only (n = 11). The treatment was well-tolerated. Whereas there was no significant inter-group difference in the clinical response rate, premature disengagement occurred less frequently in the antipsychotic-treated patients (9.5% versus 45%; Fisher's Exact Test P = 0.0318). Conclusions. BDD frequently presents with co-morbidity, treatment-resistance and premature disengagement. Adjunctive antipsychotic was associated with significantly better treatment adherence, but responder rates did not differ significantly, possibly related to the small sample-size. A well-powered randomised controlled study is warranted, to determine clinical outcomes with adjunctive antipsychotic in BDD.
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