Journal
MOLECULAR BIOSYSTEMS
Volume 11, Issue 4, Pages 1029-1040Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4mb00710g
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Funding
- Doctor Innovation funding of Shanghai Jiao Tong University School of Medicine [BXJ201213]
- National Natural funding of China [81202087, 81202088, 81172520]
- Shanghai Municipal Science and Technology Commission funding [12ZR1446400, 12140901503]
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Whether and how cancer-associated fibroblasts induce trastuzumab resistance in HER2+ breast cancer is still elusive. We analyzed the percentage of cancer stem cells and multiple pathway status before and after trastuzumab treatment in HER2 positive breast cancer cells co-cultured with conditional medium (CM) from CAFs. The results suggest that CAFs induce trastuzumab resistance by expanding cancer stem cells and activating multiple pathways, such as NF-kappa B, JAK/STAT3 and PI3K/AKT; combination of an anti-IL6 antibody, or multiple pathway inhibitors with trastuzumab in HER2 positive breast cancer maybe a novel strategy to reverse trastuzumab resistance.
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