Journal
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
Volume 63, Issue 12, Pages 609-619Publisher
TAYLOR & FRANCIS AS
DOI: 10.1080/00914037.2013.854234
Keywords
nanofibers; Box-Behnken design; ionic interaction; green electrospinning; cytotoxicity; Anticancer; sustained release
Categories
Funding
- Drug Applied Research Center
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Biocompatible and pH-sensitive poly (N-isopropylacrylamide-co-methacrylic acide-co-vinylpyrrolidone) [P(NIPAAm-MAA-VP)] nanofibers were prepared as a delivery vehicle for sustained release of doxorubicin hydrochloride (DOX) as an anticancer drug. The structure and morphology of nanofibers were investigated by SEM, FTIR, and XRD. P(NIPAAm-MAA-VP)-DOX complex was formed at pH 7 because of ionic interactions between DOX and polymers. P (NIPAAm-MAA-VP) nanofibers tailored to desire diameters with bead free morphology by optimizing the electrospinning parameters DOX release from P (NIPAAm-MAA-VP)/DOX complex was investigated as a biological on-off switch for the design of an intelligent drug delivery system triggered by external pH changes.
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