Journal
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
Volume 64, Issue 2, Pages 55-63Publisher
TAYLOR & FRANCIS AS
DOI: 10.1080/00914037.2014.886236
Keywords
dual thermo-/pH-responsive; injectable drug delivery; oscillatory rheological measurement; Anticancer; complexation; biocompatible nanogels
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Funding
- Drug Applied Research Center [91/91]
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In the present work, the preparation of dual thermo-/pH-responsive nanogels composed poly (NIPAAm-MAA-VP) was investigated as an injectable carrier in which doxorubicin hydrochloride (DOX) was opted as an anticancer agent. The SEM photomicrographs showed that copolymer was almost spherical in shape with the mean diameter below 30nm. Using dynamic oscillatory the gel-like behavior was observed at 37 degrees C for the crosslinked polymer. Biocompatibility of the synthesized nanoparticles and superior antitumor activity of DOX-loaded nanoparticles were proved by in vitro cytotoxicity assay. The system is expected to be valuable for the delivery of chemotherapeutic agents in the treatment of solid tumors. [GRAPHICS]
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