Journal
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
Volume 63, Issue 6, Pages 330-336Publisher
TAYLOR & FRANCIS AS
DOI: 10.1080/00914037.2013.845187
Keywords
Artificial conduit; gelatin-modified nanofibrous PHBV; histological assessments; sciatic regeneration
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Funding
- Islamic Azad University, Tonekabon Branch [73/442453]
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A modified nanofibrous poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nerve conduit has been used to evaluate its efficiency based on the promotion of peripheral nerve regeneration in rats. The authors used a gelatin-modified nanofibrous poly (3-hydroxybutyrate-co-3-hydroxyvalerate) nerve conduit to bridge a 30mm long gap in the rat sciatic nerve. At four months after nerve conduit implantation, regenerated nerves were macroscopically observed and histologically assessed. In the nanofibrous graft, the rat sciatic nerve trunk had been reconstructed by restoration of nerve continuity and formation of myelinated nerve fiber. There were Schwann cells and glial cells in the regenerated nerves. These findings suggest that modified nanofibrous poly(3-hydroxybutyrate-co-3- hydroxyvalerate) nerve conduit is suitable for repair of long-segment sciatic nerve defects.
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