Journal
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
Volume 62, Issue 11, Pages 605-611Publisher
TAYLOR & FRANCIS AS
DOI: 10.1080/00914037.2013.769165
Keywords
Amoxicillin; chitosan; drug delivery; glutaraldehyde; hydrogel
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Chitosan was crosslinked with different amount of glutaraldehyde to prepare appropriate hydrogels to be used as drug delivery system. The swelling behavior of freeze-dried hydrogels in aqueous media at different temperature and pHs has been examined. The swelling, porosity and biocompatibility behavior of samples were investigated to check effects of polymer/polymer and polymer/drug interactions on these system characteristics. Obtained experimental results illustrates that with increasing crosslinking agent from 0.068 to 0.30, swelling of the prepared samples degrees from 1200% to 600% and pore diameters change from 100 to 500 mu m. To investigate systems biocompatibility in gastric conditions, effects of crosslinker concentration on the pepsin enzyme activity have been studied using variation of relative viscosity of the system. Presented results also show that with increasing crosslinker agent concentration activity of enzyme reduces considerably and so crosslinker molar ratio to amine functional groups of chitosan must be less than 0.2.
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