Journal
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
Volume 62, Issue 7, Pages 384-389Publisher
TAYLOR & FRANCIS AS
DOI: 10.1080/00914037.2012.710862
Keywords
Compression; 3-D sponge; freeze-drying; gelatin; human fibroblast; PVA; skin tissue engineering
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Funding
- Yeungnam University
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A series of PVA/gelatin scaffolds in different concentrations were prepared and blended to evaluate the polymer concentration effects on the architecture of the scaffold. SEM images revealed that with increasing gelatin concentration the average pore diameters varied from 60 to 190nm. Bio-compatibility assay showed cells attached and elongated actively on the scaffolds and cyto-toxicity results of all samples were found to be in grade 1 or 0, indicating the bio-safety of PVA/gelatin as biomaterial. Results indicate the polymer concentration effects on the architecture of the scaffold and PVA/gelatin macroporous scaffolds have potential to be bio-matrices for tissue genesis.
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