Journal
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
Volume 62, Issue 14, Pages 763-769Publisher
TAYLOR & FRANCIS AS
DOI: 10.1080/00914037.2013.769239
Keywords
Epirubicin; hydrogel; in situ gelling; oral administration; pH-sensitive; thermo-responsive
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Funding
- National Science Council of Taiwan [NSC97-2221-E-024-001]
- National University of Tainan [AB100-318, AB101-316]
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In situ gelling formulations composed of pluronic (Plu) and poly(acrylic acid) (PAA) were prepared for oral delivery the antitumor drug, epirubicin. The physicochemical properties, including swelling ratio, viscosity, and gel strength of these formulations with three different concentrations of PAA were characterized. Formulations all developed hydrogel forms and thus released epirubicin in a sustained way in vitro. The assay of the formulations with different epirubicin concentrations on growth inhibition of CT-26 (mouse colon adenocarcinoma) cells reveals cell viability % is decreased dose-dependently. This study highlights the advantages of using dual phase transition hydrogel to deliver antitumor drugs.
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