Journal
ANNALS OF THORACIC SURGERY
Volume 99, Issue 3, Pages 1005-1012Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.athoracsur.2014.10.016
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Funding
- Ceremed, the producer of Ostene
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Background. Sternotomy is the preferred access to the mediastinum. During sternotomy, trabecular bone is exposed, often resulting in bleeding, which can be treated with mechanical hemostatic agents; however, their influence on the healing process is relatively unexplored. The aim of this study was to investigate the influence of two hemostatic agents: bone wax (BW) and a water-soluble polymer wax, Ostene (WSW), on the mechanical and histologic characteristics of healing sternal bone. Methods. Twenty-four pigs underwent sternotomy and were randomized into three groups: WSW, BW, or no hemostatic treatment (control). Bone samples were obtained 6 weeks postoperatively. Results. Fracture strength (F-max) and maximum stiffness (dF/dx) was lower in the BW group than in controls (F-max : 175.2 vs. 255.8N, dF/dx: 165.2 vs. 375.4N/mm,) (p < 0.05). The stiffness did not differ statistically between the WSW and BW groups (298.4 vs 165.2 N/mm) nor did the fracture strength (211.4 vs 175.2 N). The fraction of granulomatous tissue was higher in the BW group compared with both the WSW group (79.1 vs. 16.52%) (p < 0.001) and controls (79.1 vs. 11.2%) (p < 0.001). There was more calcified tissue in controls than in the BW group (23.4 vs. 10.8%) (p < 0.05). Conclusions. In a porcine model, BW significantly inhibited sternal healing and was associated with chronic inflammation and reduced mechanical integrity. The WSW did not, to the same degree as BW, inhibit bone healing and thus presents an alternative treatment option for sternal bleeding. (C) 2015 by The Society of Thoracic Surgeons
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