Journal
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS
Volume 60, Issue 7, Pages 456-468Publisher
TAYLOR & FRANCIS AS
DOI: 10.1080/00914037.2010.531814
Keywords
carboxymethylation; glucose acrylate; perlite; pH-sensitive; polymer grafting
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Funding
- Office of Research Vice Chancellor of Azarbaijan University of Tarbiat Moallem
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The free-radical graft polymerization of hydrophobic glycomonomer onto surface-activated perlite particles was studied experimentally. The grafting procedure consisted of surface activation with 3-(trimethoxysilyl) propyl methacrylate (TSPA), followed by free-radical graft polymerization of glucose acrylate (GA), using persulfate as an initiator. pH-Sensitive hydrogel synthesis was carried out by carboxymethylation mixing composite with sodium monochloroacetate (SMCA). Insulin was entrapped in these gels and the in vitro release profiles were established separately in both (SGF, pH 1) and (SIF, pH 7.4).
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