Journal
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS
Volume 59, Issue 10, Pages 793-807Publisher
TAYLOR & FRANCIS AS
DOI: 10.1080/00914037.2010.483219
Keywords
antibacterial activity; chitosan; ofloxacin; SEM
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Funding
- CSIR
- UGC, New Delhi
- Royal Society of Chemistry
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A novel chitosan derivative with ofloxacin (OFX) has been successfully prepared. The IR and 1H-NMR results revealed that the chitosan/ofloxacin (CH-OFX) complex exhibited an electrostatic interaction. The crystalline and surface morphology were analyzed by X-ray diffraction (XRD) and scanning electron microscopy (SEM). The antimicrobial activity of the complexes against various micro-organisms viz. Escherichia coli, Bacillus subtilis, Pseudomonas aeruginosa and Staphylococcus aureus was tested. It was established that their antibacterial activity is up to four times greater than that of free quinolone drug and chitosan, probably due to the conjunction of favorable pharmacokinetics, excellent bacterial susceptibility and good stability towards metabolic degradation.
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