Journal
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume 550, Issue 1-2, Pages 251-268Publisher
ELSEVIER
DOI: 10.1016/j.ijpharm.2018.08.043
Keywords
Aggregate; Particulate; Opalescence; Oligomerization; Conformation; Colloidal stability
Categories
Ask authors/readers for more resources
Protein aggregation has been recognized as one of the major challenges in the development and commercialization of successful protein-based drug products because of the inherent and high aggregation tendency during various manufacturing processes, storage, and administration. Protein aggregates may impact significantly the product quality, safety and/or efficacy. This review is intended to summarize four major aspects of protein aggregation - (1) aggregation mechanisms, (2) aggregation-influencing factors, (3) detection of protein aggregates, and (4) control of protein aggregation based on recent literature in this area.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available