Journal
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume 461, Issue 1-2, Pages 519-528Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijpharm.2013.12.007
Keywords
Nanoliposome; Cancer cells; Lecithin; Drug encapsulation
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Funding
- Syrian Ministry of Higher Education and Aleppo-University
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The role of curcumin (diferuloylmethane), for cancer treatment has been an area of growing interest. However, due to its low absorption, the poor bioavailability of curcumin limits its clinical use. In this study, we reported an approach of encapsulation a curcumin by nanoliposome to achieve an improved bioavailability of a poorly absorbed hydrophobic compound. We demonstrated that liposomal preparations to deliver curcumin increase its bioavailability. Liposomes composed of salmon's lecithin also improved curcumin bioavailability compared to those constituted of rapeseed and soya lecithins. A realtime label-free cell analysis system based on real-time cell impedance monitoring was used to investigate the in vitro cytotoxicity of liposomal preparations. (C) 2013 Elsevier B.V. All rights reserved.
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