Journal
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume 463, Issue 1, Pages 22-26Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijpharm.2013.12.045
Keywords
Controlled release; Mesoporous silica nanoparticles; Polydopamine; Drug delivery
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Funding
- NSFC [21177023]
- Key Project of Chinese Ministry of Education [211084]
- Science Foundation of Fujian Province of China [2013101044]
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A novel pH-sensitive controlled release system is proposed by using mussel-inspired polydopamine (PDA) coated mesoporous silica nanoparticles (MSNs) as nanocarriers.MSNs with a large pore diameter are synthesized by using 1,3,5-trimethylbenzene as a pore-expanding agent and are modified with a PDA coating by virtue of oxidative self-polymerization of dopamine in neutral pH. PDA coated MSNs are characterized by FTIR, TEM, N2 adsorption and XPS techniques. The PDA coating can work as pH-sensitive gatekeepers to control the release of drug molecules from MSNs in response to the pH-stimulus. Doxorubicin (DOX, an anticancer drug) can be released in the acid media and blocked in the neutral media. (C) 2014 Elsevier B.V. All rights reserved.
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