Journal
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume 475, Issue 1-2, Pages 566-577Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijpharm.2014.09.026
Keywords
Guided tissue regeneration; Electrospinning; PCL; Metronidazole; Anti-infection; Controlled delivery
Categories
Funding
- National Natural Science Foundation of China [50933001, 51221102, 51303014]
- National Outstanding Youth Science Fund [50725310]
- National Basic Research Program (973 Program) of China [2011CB606003]
- Beijing Nova Program [Z131102000413015]
- Beijing Municipal Training Programme Foundation for the Talents [2013D00303400041]
- RCUK China-UK Science Bridges Program through the Medical Research Council
- Engineering and Physical Sciences Research Council
- Engineering and Physical Sciences Research Council [EP/K029592/1, EP/L020572/1, EP/L027011/1, EP/K004204/1] Funding Source: researchfish
- EPSRC [EP/L020572/1, EP/K029592/1, EP/L027011/1, EP/K004204/1] Funding Source: UKRI
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Infection is the major reason of GTR/GBR membrane failure in clinical application. In this work, we developed GTR/GBR nanofiber membranes with localized drug delivery function to prevent infection. Metronidazole (MNA), an antibiotic, was successfully incorporated into electrospun polycaprolactone (PCL) nanofibers at different concentrations (0, 1, 5, 10, 20, 30, and 40 wt% polymer). To obtain the optimum anti-infection membrane, we systematically investigated the physical-chemical and mechanical properties of the nanofiber membranes with different drug contents. The interaction between PCL and MNA was identified by molecular dynamics simulation. MNA released in a controlled, sustained manner over 2 weeks and the antibacterial activity of the released MNA remained. The incorporation of MNA improved the hydrophilicity and in vitro biodegradation rate of PCL nanofibers. The nanofiber membranes allowed cells to adhere to and proliferate on them and showed excellent barrier function. The membrane loaded with 30% MNA had the best comprehensive properties. Analysis of subcutaneous implants demonstrated that MNA-loaded nanofibers evoked a less severe inflammatory response than pure PCL nanofibers. These results demonstrate the potential of MNA-loaded nanofiber membranes as GTR/GBR membrane with antibacterial and anti-inflammatory function for extensive biomedical applications. (C) 2014 Elsevier B.V. All rights reserved.
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