Journal
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume 453, Issue 1, Pages 36-43Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijpharm.2013.05.013
Keywords
Drug precipitation; Precipitation inhibitors; Supersaturable formulations; Poorly water soluble compounds; Bioavailability
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Use of supersaturable formulations has been demonstrated as an effective approach to improve solubility and oral absorption of poorly water-soluble compounds. In supersaturable formulations, drug concentration exceeds the equilibrium solubility when the formulations are exposed to the gastrointestinal fluids and drug might precipitate before being absorbed, resulting in delayed response, and reduced efficacy or compromised bioavailability. Polymer based drug precipitation inhibitors have been used to inhibit or retard such precipitation. In this manner one can maintain a drug in the supersaturated concentration for an extended period of time, leading to significantly improved bioavailability of the poorly water-soluble drugs. This review article discusses different types of precipitation inhibitors, working hypotheses, and case studies with improved oral bioavailability. (c) 2013 Elsevier B.V. All rights reserved.
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