Journal
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume 446, Issue 1-2, Pages 63-69Publisher
ELSEVIER
DOI: 10.1016/j.ijpharm.2013.02.011
Keywords
MIC; Kanamycin sulfate; Silica; Antimicrobial therapy; Caprolactam
Categories
Funding
- Sectorial Operational Programme Human Resources Development
- European Social Fund
- Romanian Government [POSDRU/86/1.2/S/58146]
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Here, we report the fabrication of a novel epsilon-caprolactam-silica (epsilon-SiO2) network and assessed its biocompatibility and ability to improve the antimicrobial activity of kanamycin. The results of the quantitative antimicrobial assay demonstrate that the obtained epsilon-SiO2 network has efficiently improved the kanamycin activity on Staphylococcus aureus ATCC 25923 and Escherichia coli ATCC 25922 strains, with a significant decrease of the minimum inhibitory concentration. The epsilon-SiO2 network could be feasibly obtained and represents an alternative for the design of new antibiotic drug carriers or delivery systems to control bacterial infections. (C) 2013 Elsevier B. V. All rights reserved.
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