Journal
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume 450, Issue 1-2, Pages 296-303Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijpharm.2013.04.014
Keywords
Mesoporous silica nanoparticle; pH; sensitive; Poly(L glimaticlutamic acid); Drug delivery; DOX
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Funding
- National Science Foundation of China [20874015, 51273047]
- Shanghai Rising-Star Program [10QH1400200]
- Shanghai Municipal Education Commission and Shanghai Education Development Foundation [12SG07]
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pH-(sensitive poly(L-(glutamic acid) grafted mesoporous silica nanoparticles (MSN-(PLGA) were prepared by the surface-(initiated N-(carboxyanhydride polymerization method. The resultant MSN-(PLGA was well dispersed in aqueous medium and showed high drug loading efficiency, superior stability, and significantly higher drug release rates. The cumulative release of doxorubicin hydrochloride (DOX) from DOX-(loaded MSN-(PLGA (DOX@ MSN-(PLGA) was pH-(dependent and the release rate was much higher at pH 5.5 than that at pH 7.4. The cytotoxicity results indicated that the blank MSN-(PLGA was biocompatible and the DOX@ MSN-(PLGA had potent in vitro cytotoxicity effect similar to free DOX. Overall, these results demonstrate that MSN-(PLGA is a promising platform to build pH controlled drug delivery systems for cancer therapy. (C) 2013 Elsevier B.V. All rights reserved.
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