Journal
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume 436, Issue 1-2, Pages 771-777Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijpharm.2012.07.063
Keywords
Prokaryotic cells; Eukaryotic cells; Magnetic chitosan; Magnetic cellulose; Magnetic composite
Categories
Funding
- National Research project Human Resources 135 [76/2010]
- National Research project Ideas [154/2011]
Ask authors/readers for more resources
Preparation and characterization of CS/Fe3O4/CMC composite scaffolds including the morphology, crystallinity, and the in vitro efficacy as antibiotic delivery vehicles as well as their influence on the eukaryotic cells are reported. The results demonstrated that the magnetic polymeric composite scaffolds are exhibiting structural and functional properties that recommend them for further applications in the biomedical field. They improve the activity of currently used antibiotics belonging to penicillins, macrolides, aminoglycosides, rifampicines and quinolones classes, representing potential macromolecular carriers for these antimicrobial substances, to achieve extracellular and intracellular targets. The obtained systems are not cytotoxic and do not influence the eukaryotic HCT8 cell cycle, representing potential tools for the delivery of drugs in a safe, effective and less expensive manner. (c) 2012 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available