Journal
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume 436, Issue 1-2, Pages 568-573Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijpharm.2012.07.014
Keywords
Halloysite; Drug; Polymer; Delivery system
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Funding
- Sectoral Operational Programme Human Resources Development of the Romanian Ministry of Labour, Family and Social Protection [POSDRU/88/1.5/S/61178]
- Executive Agency for Higher Education and Research Funding (UEFISCSU)
- National Research Council (CNCS) [TE-142, 5/4.08.2010]
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New hybrid materials based on a natural host (halloysite), biodegradable polymer (poly(vinyl alcohol)) and diphenhydramine hydrochloride as drug were synthesized and tested as a potential controlled drug delivery system. The formation of these hybrid materials was proved using different characterization methods like Spectroscopic techniques (FTIR, XPS and UV-vis), thermogravimetrical analysis and scanning electron microscopy (SEM). The hybrid materials exhibit different features regarding the drug release. In vitro drug release tests showed that there are several factors which exhibit a strong influence on the drug release rate. Thus the initial drug concentration used at the hybrid materials synthesis, the presence of a polymer in the hybrid composition and the pH value of the release medium are the most important factors. (c) 2012 Published by Elsevier B.V.
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