Journal
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume 436, Issue 1-2, Pages 201-205Publisher
ELSEVIER
DOI: 10.1016/j.ijpharm.2012.06.031
Keywords
Magnetic chitosan beads; Cephalosporins; Antibacterial activity; Chitosan microspheres
Categories
Funding
- Human Resources [135/2010, 76/2010]
- PNII, IDEI [154/2011]
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During the present study, we have evaluated magnetic chitosan as a potential drug delivery device, by specifically determining if chitosan could elute antibiotics in an active form that would be efficacious in inhibiting Staphylococcus aureus and Escherichia coli growth. We have demonstrated that the incorporation of cephalosporins of second, third and fourth generation into magnetic chitosan microspheres can possibly lead to an improved delivery of antibiotics in active forms, probably due to the inherent properties of chitosan. (c) 2012 Elsevier B.V. All rights reserved.
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