Journal
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume 439, Issue 1-2, Pages 63-72Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijpharm.2012.09.045
Keywords
Dissolution; Eutectic; Nicotinamide; Solubility; Thermal analysis
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Funding
- UGC
- Department of Science and Technology [SR/S2/JCB-06/2009]
- Council of Scientific and Industrial Research [01/2410)/10/EMR-II]
- University Grants Commission (UGC) (PURSE grant)
- CSIR
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The bioactive herbal ingredient curcumin was screened with pharmaceutically acceptable coformers to discover solid-state forms of high solubility. Mechano-chemical grinding of curcumin with cocrystal formers in a fixed stoichiometry ratio resulted in binary eutectic compositions of curcumin-coformer with nicotinamide (1: 2), ferulic acid (1: 1), hydroquinone (1: 1), p-hydroxybenzoic acid (1: 1), and L-tartaric acid (1: 1). The eutectic nature of the product crystalline solids was established by differential scanning calorimetry, and the absence of hydrogen-bonded crystalline phases such as cocrystals/salts was ascertained by powder X-ray diffraction, IR-Raman, and solid-state NMR spectroscopy. The best case of CUR-NAM eutectic exhibits 10-fold faster IDR and 6-times higher AUC compared to crystalline curcumin. (C) 2012 Elsevier B. V. All rights reserved.
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