Journal
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume 434, Issue 1-2, Pages 460-467Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijpharm.2012.06.019
Keywords
Lipid nanocapsules; Drop tensiometer; Dialysis; Tangential flow filtration; Rheology
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Funding
- French National Research Agency (ANR) [ANR-08-NANO-006]
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Deformability of nanoparticles might affect their behaviour at biological interfaces. Lipid nanocapsules (LNCs) are semi-solid particles resembling a hybrid of polymer nanoparticles and liposomes. Deformability of LNCs of different sizes was modelled by drop tensiometer technique. Two purification methods, dialysis and tangential flow filtration (TFF), were applied to study experimental behaviour and deformability of LNCs in order to evaluate if these properties contributed to membrane passing. Rheological parameters obtained from the drop tensiometer analysis suggested decreasing surface deformability of LNCs with increase in diameter. Dialysis results showed that up to 10% of LNCs can be lost during the process (e. g. membrane accumulation) but no clear evidence of the membrane passing was observed. Instead, LNCs with initial size and size distribution could be found in the TFF filtrate although molecular weight cut-off (MWCO) of the membrane used was smaller than the LNC diameter. (C) 2012 Elsevier B.V. All rights reserved.
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